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Ruboxistaurin說明

發(fā)布日期:2018-04-23   瀏覽次數(shù):0
核心提示:Ruboxistaurin hydrochlorid是蛋白激酶C的抑制劑,是PKCβI 和 PKCβII競(jìng)爭(zhēng)性可逆的抑制劑,IC50分別是4.7 nM和5.9 nM.
Ruboxistaurin hydrochlorid是蛋白激酶C的抑制劑,是PKCβI 和 PKCβII競(jìng)爭(zhēng)性可逆的抑制劑,IC50分別是4.7 nM和5.9 nM.
Remodelin產(chǎn)品描述:Remodelin is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10. IC50 value: Target: NAT10 inhibitor Remodelin can improve nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and HGPS-derived patient cells, and decrease markers of DNA damage in these cells. Using a combination of chemical, cellular, and genetic approaches, acetyl-transferase protein NAT10 was identified as the target of Remodelin that mediated nuclear shape rescue in laminopathic cells via microtubule reorganization. Down-regulation and mutations of the nuclear-architecture proteins lamin A and C cause misshapen nuclei and altered chromatin organization associated with cancer and laminopathies, including the premature-aging disease Hutchinson-Gilford progeria syndrome (HGPS). Remodelin is a useful chemical tool to study how NAT10 affects nuclear architecture and suggest alternative strategies for treating laminopathies and aging.


公司介紹:MedChemExpress(MCE)專注于各種抑制劑、激動(dòng)劑、API及化合物庫(kù),總部位于美國(guó)新澤西,分別在瑞典和上海設(shè)有歐洲區(qū)子公司和亞洲區(qū)總代理,營(yíng)銷網(wǎng)點(diǎn)遍及全球20多個(gè)國(guó)家地區(qū)。MCE經(jīng)過多年努力已成為全球生物活性小分子領(lǐng)域的一流供應(yīng)商, 產(chǎn)品涵蓋癌癥、神經(jīng)科學(xué)、抗感染、表觀遺傳學(xué)等20個(gè)熱門研究領(lǐng)域,PI3K、MAPK等近千個(gè)細(xì)分靶點(diǎn),超過4000個(gè)活性小分子化合物現(xiàn)貨,以及GPCR、API、離子通道等超過20種不同類型的化合物庫(kù),同時(shí)提供從毫克到千克的專業(yè)定制合成服務(wù)。
MCE 對(duì)每批產(chǎn)品都進(jìn)行嚴(yán)格的LCMS和NMR檢驗(yàn),其產(chǎn)品已被全球近萬名客戶廣泛使用并發(fā)表大量文章、專利;
MCE 定期增加各領(lǐng)域熱門抑制劑、激動(dòng)劑,不斷擴(kuò)增已有化合物庫(kù),以滿足最新的科研需求;
數(shù)千種產(chǎn)品在上海有充足備貨,24-48小時(shí)內(nèi)送達(dá)客戶;
大量產(chǎn)品提供免費(fèi)試用裝; 已為全球多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫(kù)。

產(chǎn)品鏈接:www.medchemexpress.cn/Remodelin.html


Purity:98%
MWt:505.0079
Formula:C28H29ClN4O3
SMILES:O=C1NC(C(C2=CN(C3=CC=CC=C32)CCO[C@H](CN(C)C)CC4)=C1C5=CN4C6=CC=CC=C56)=O.[H]Cl
Pathway:Epigenetics; TGF-beta/Smad;
Mechanisms:PKC;
Research Area:Cancer
電話: 021-58955995
網(wǎng)址: www.MedChemExpress.cn
地址: 上海市浦東新區(qū)蔡倫路720號(hào)2號(hào)樓3層
 
關(guān)鍵詞: Ruboxistaurin
 
 
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