PKC412 是一種蛋白激酶C (PKC) 的抑制劑,同時(shí)可抑制 PKC 亞型 (α,β,γ),PDFRβ,VEGFR2,Syk,PKCη,F(xiàn)lk-1,F(xiàn)lt3,Cdk1/B,PKA,c-Kit,c-Fgr,c-Src,VEGFR1 和 EGFR。
CNDAC產(chǎn)品描述:CNDAC is a major metabolite of oral drug sapacitabine, and a nucleoside analog. In Vitro: CNDAC-induced SSBs can be repaired by the transcription-coupled nucleotide excision repair pathway, wheras lethal DSBs are mainly repaired through homologous recombination. Deficiency in two Rad51 paralogs, Rad51D and XRCC3, greatly sensitize cells to CNDAC. The Rad51D-null cell line is approximately 50-fold more sensitive to CNDAC (IC50=0.006 μM) compared to 51D1.3, the Rad51D-repleted line (IC50=0.32 μM)[1]. CNDAC shows inhibitory activity against HL-60 and THP-1 cells with IC50s of 1.58 μM and 0.84 μM. CNDAC (10?μM) results in a significant dro in cell survival compared to the untreated on days 4, 7, and 14. CNDAC is more effective at reducing viability and inducing apoptosis than ara-C at equivalent concentrations in the THP-1 cell line, which is defined as displaying resistance to ara-C[2]. CNDAC induces DSBs, which are
公司介紹:MedChemExpress(MCE)專注于各種抑制劑、激動(dòng)劑、API及化合物庫(kù),總部位于美國(guó)新澤西,分別在瑞典和上海設(shè)有歐洲區(qū)子公司和亞洲區(qū)總代理,營(yíng)銷網(wǎng)點(diǎn)遍及全球20多個(gè)國(guó)家地區(qū)。MCE經(jīng)過(guò)多年努力已成為全球生物活性小分子領(lǐng)域的一流供應(yīng)商, 產(chǎn)品涵蓋癌癥、神經(jīng)科學(xué)、抗感染、表觀遺傳學(xué)等20個(gè)熱門研究領(lǐng)域,PI3K、MAPK等近千個(gè)細(xì)分靶點(diǎn),超過(guò)4000個(gè)活性小分子化合物現(xiàn)貨,以及GPCR、API、離子通道等超過(guò)20種不同類型的化合物庫(kù),同時(shí)提供從毫克到千克的專業(yè)定制合成服務(wù)。
MCE 對(duì)每批產(chǎn)品都進(jìn)行嚴(yán)格的LCMS和NMR檢驗(yàn),其產(chǎn)品已被全球近萬(wàn)名客戶廣泛使用并發(fā)表大量文章、專利;
MCE 定期增加各領(lǐng)域熱門抑制劑、激動(dòng)劑,不斷擴(kuò)增已有化合物庫(kù),以滿足最新的科研需求;
數(shù)千種產(chǎn)品在上海有充足備貨,24-48小時(shí)內(nèi)送達(dá)客戶;
大量產(chǎn)品提供免費(fèi)試用裝; 已為全球多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫(kù)。
產(chǎn)品鏈接:www.medchemexpress.cn/CNDAC.html
Purity:98%
MWt:570.6371
Formula:C35H30N4O4
SMILES:O=C(C1=CC=CC=C1)N(C)[C@H]2[C@@H](OC)[C@@]3(C)N(C4=C5C=CC=C4)C6=C5C7=C(C(NC7)=O)C8=C6N(C9=CC=CC=C98)[C@@](O3)([H])C2
Pathway:Epigenetics; TGF-beta/Smad;
Mechanisms:PKC;
Research Area:Cancer
電話: 021-58955995
網(wǎng)址: www.MedChemExpress.cn
地址: 上海市浦東新區(qū)蔡倫路720號(hào)2號(hào)樓3層
CNDAC產(chǎn)品描述:CNDAC is a major metabolite of oral drug sapacitabine, and a nucleoside analog. In Vitro: CNDAC-induced SSBs can be repaired by the transcription-coupled nucleotide excision repair pathway, wheras lethal DSBs are mainly repaired through homologous recombination. Deficiency in two Rad51 paralogs, Rad51D and XRCC3, greatly sensitize cells to CNDAC. The Rad51D-null cell line is approximately 50-fold more sensitive to CNDAC (IC50=0.006 μM) compared to 51D1.3, the Rad51D-repleted line (IC50=0.32 μM)[1]. CNDAC shows inhibitory activity against HL-60 and THP-1 cells with IC50s of 1.58 μM and 0.84 μM. CNDAC (10?μM) results in a significant dro in cell survival compared to the untreated on days 4, 7, and 14. CNDAC is more effective at reducing viability and inducing apoptosis than ara-C at equivalent concentrations in the THP-1 cell line, which is defined as displaying resistance to ara-C[2]. CNDAC induces DSBs, which are
公司介紹:MedChemExpress(MCE)專注于各種抑制劑、激動(dòng)劑、API及化合物庫(kù),總部位于美國(guó)新澤西,分別在瑞典和上海設(shè)有歐洲區(qū)子公司和亞洲區(qū)總代理,營(yíng)銷網(wǎng)點(diǎn)遍及全球20多個(gè)國(guó)家地區(qū)。MCE經(jīng)過(guò)多年努力已成為全球生物活性小分子領(lǐng)域的一流供應(yīng)商, 產(chǎn)品涵蓋癌癥、神經(jīng)科學(xué)、抗感染、表觀遺傳學(xué)等20個(gè)熱門研究領(lǐng)域,PI3K、MAPK等近千個(gè)細(xì)分靶點(diǎn),超過(guò)4000個(gè)活性小分子化合物現(xiàn)貨,以及GPCR、API、離子通道等超過(guò)20種不同類型的化合物庫(kù),同時(shí)提供從毫克到千克的專業(yè)定制合成服務(wù)。
MCE 對(duì)每批產(chǎn)品都進(jìn)行嚴(yán)格的LCMS和NMR檢驗(yàn),其產(chǎn)品已被全球近萬(wàn)名客戶廣泛使用并發(fā)表大量文章、專利;
MCE 定期增加各領(lǐng)域熱門抑制劑、激動(dòng)劑,不斷擴(kuò)增已有化合物庫(kù),以滿足最新的科研需求;
數(shù)千種產(chǎn)品在上海有充足備貨,24-48小時(shí)內(nèi)送達(dá)客戶;
大量產(chǎn)品提供免費(fèi)試用裝; 已為全球多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫(kù)。
產(chǎn)品鏈接:www.medchemexpress.cn/CNDAC.html
Purity:98%
MWt:570.6371
Formula:C35H30N4O4
SMILES:O=C(C1=CC=CC=C1)N(C)[C@H]2[C@@H](OC)[C@@]3(C)N(C4=C5C=CC=C4)C6=C5C7=C(C(NC7)=O)C8=C6N(C9=CC=CC=C98)[C@@](O3)([H])C2
Pathway:Epigenetics; TGF-beta/Smad;
Mechanisms:PKC;
Research Area:Cancer
電話: 021-58955995
網(wǎng)址: www.MedChemExpress.cn
地址: 上海市浦東新區(qū)蔡倫路720號(hào)2號(hào)樓3層