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SDMA研究進(jìn)展

發(fā)布日期：2017-10-30   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/SDMA.htmlSDMA/a產(chǎn)品描述：SDMA (Symmetric dimethylarginine) is an endogenous inhibi
<a href="https://www.medchemexpress.com/SDMA.html">SDMA</a>產(chǎn)品描述：SDMA (Symmetric dimethylarginine) is an endogenous inhibitor of nitric oxide (<b>NO</b>) synthase activity.

<i><b>In Vitro:</b></i> SDMA is the structural isomer of the cardiovascular risk marker asymmetric dimethylarginine, as an endogenous marker of renal function. SDMA does not directly inhibit NOS but is a competitor of arginine transport. SDMA is primarily eliminated by renal excretion and is a promising endogenous marker of glomerular filtration rate<sup>[1]</sup>. SDMA inhibits dose dependently the NO synthesis in intact endothelial cells, wheras it has no effect on protein expression of NOS<sup>[1]</sup>. SDMA is involved in the inflammatory process of chronic kidney disease, activating NF-κB and resulting in enhanced expression of IL-6 and TNF-α<sup>[2]</sup>.



<i><b>In Vivo:</b></i> SDMA is highly stable in serum and plasma, and the assay demonstrates excellent analytical performance. In unaffected dogs, SDMA remains unchanged wheras in affected dogs, SDMA increases dur<br><br>
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