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Thyroxine sulfate研究進展

發(fā)布日期：2017-10-30   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/Thyroxine_sulfate.htmlThyroxine sulfate/a產(chǎn)品描述：Thyroxine sulfate is a thyroid
<a href="https://www.medchemexpress.com/Thyroxine_sulfate.html">Thyroxine sulfate</a>產(chǎn)品描述：Thyroxine sulfate is a thyroid hormone metabolite.

<i><b>In Vitro:</b></i> Thyroxine sulfate (T4S) is a normal component of human serum and amniotic fluid, and it is mostly derived from thyroxine peripherally and accumulates when type I 5-monodeiodinating activity is low in fetuses or inhibited by drugs, such as ipodate<sup>[1]</sup>.

<i><b>In Vivo:</b></i> Significant amounts of thyroxine sulfate (T4S) in fetal sheep serum, meconium, bile, and amniotic and allantoic fluids are observed. T4S concentration in amniotic fluid from women at 18-19 weeks of gestation (25.5 ng/dL) is higher than that at 14-15 weeks of gestation (14.3 ng/dL). A significant rise in serum T4S is detected in hyperthyroid patients 1 day after ingestion of 1 g of ipodate<sup>[1]</sup>. Thyroxine undergoes significant sulfation in rats, and biliary excretion of T4S is enhanced if its type I deiodination is inhibited<sup>[2]</sup>. Serum T4S levels are clearly elevated compared with healthy references, and the dec<br><br>
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