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STK16-IN-1研究進展

發(fā)布日期：2017-10-27   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/STK16-IN-1.htmlSTK16-IN-1/a產(chǎn)品描述：STK16-IN-1 is a bSTK16/b kinase inhibitor wit
<a href="https://www.medchemexpress.com/STK16-IN-1.html">STK16-IN-1</a>產(chǎn)品描述：STK16-IN-1 is a <b>STK16</b> kinase inhibitor with an <b>IC<sub>50</sub></b> of 295 nM.

IC50 & Target: IC50: 295 nM (STK16)<sup>[1]</sup>

<i><b>In Vitro:</b></i> STK16-IN-1, which exhibits potent inhibitory activity against STK16 kinase (IC<sub>50</sub>=0.295 μM) with excellent selective across the kinome as assessed using the KinomeScanTM profiling assay. STK16-IN-1 inhibits mTOR kinase with an IC<sub>50</sub> of 5.56 μM. In MCF-7 cells, treatment with STK16-IN-1 results in a reduction in cell number and accumulation of binucleated cells, which can be recapitulated by RNAi knockdown of STK16. Co-treatment of STK16-IN-1 with chemotherapeutics such as cisplatin, doxorubicin, colchicine and paclitaxel results in a slight potentiation of the anti-proliferative effects of the chemotherapeutics. STK16-IN-1 provides a useful tool compound for further elucidating the biological functions of STK16)<sup>[1]</sup>.

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src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"

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