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Agmatine (sulfate)研究進展

發(fā)布日期：2017-10-27   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/Agmatine_sulfate.htmlAgmatine (sulfate)/a產(chǎn)品描述：Agmatine sulfate exerts modulat
<a href="https://www.medchemexpress.com/Agmatine_sulfate.html">Agmatine (sulfate)</a>產(chǎn)品描述：Agmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis. It is an endogenous agonist at <b>imidazoline receptor</b> and a <b>NO synthase</b> inhibitor.

<i><b>In Vitro:</b></i> Agmatine binds to alpha 2-adrenergic and imidazoline receptors and stimulates release of catecholamines from adrenal chromaffin cells. Its biosynthetic enzyme, arginine decarboxylase, is present in brain. Agmatine, locally synthesized, is an endogenous agonist at imidazoline receptors, a noncatecholamine ligand at alpha 2-adrenergic receptors and may act as a neurotransmitter<sup>[1]</sup>. Agmatine is synthesized in the brain, stored in synaptic vesicles in regionally selective neurons, accumulated by uptake, released by depolarization, and inactivated by agmatinase. Agmatine inhibits nitric oxide synthase, and induces the release of some peptide hormones<sup>[2]</sup>. Agmatine, 4-(aminobutyl)guanidine, is produced by <br><br>
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