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NQ301研究進(jìn)展

發(fā)布日期：2017-10-27   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/NQ301.htmlNQ301/a產(chǎn)品描述：NQ301 is an antithrombotic agent; inhibits collagen-cha
<a href="https://www.medchemexpress.com/NQ301.html">NQ301</a>產(chǎn)品描述：NQ301 is an antithrombotic agent; inhibits collagen-challenged rabbit platelet aggregation with an <b>IC<sub>50</sub></b> of 10 mg/mL.

IC50 & Target: IC50: 0.60±0.02 μM (collagen-challenged rabbit platelet aggregation), 0.58±0.04 μM (U46619-challenged rabbit platelet aggregation), 0.78±0.04 μM (arachidonic acid-challenged rabbit platelet aggregation)<sup>[1]</sup>

<i><b>In Vitro:</b></i> NQ301 concentration-dependently inhibits collagen (10 mg/mL)-, U46619 (1 mg/mL)- and arachidonic acid (100 mg/mL)-challenged rabbit platelet aggregation, with IC<sub>50</sub>  values of 0.60±0.02, 0.58±0.04 and 0.78±0.04 μM, respectively. NQ301 potently suppresses thromboxane B<sub>2</sub> formation by platelets that are exposed to arachidonic acid in a concentration-dependent manner, but had no effect on the production of prostaglandin D<sub>2</sub>, indicating an inhibitory effect on thromboxane A<sub>2</sub> synthase. NQ301 has a potential to inhibit thromboxane A<sub>2</sub> synthase activity w<br><br>
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已為全球多個知名企業(yè)、院校構(gòu)建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a href="http://www.medchemexpress.cn/nq301.html">www.medchemexpress.cn/nq301.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"

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