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Src Inhibitor 1研究進(jìn)展

發(fā)布日期：2017-10-27   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/Src-Inhibitor-1.htmlSrc Inhibitor 1/a產(chǎn)品描述：Src Inhibitor 1 is a potent and sel
<a href="https://www.medchemexpress.com/Src-Inhibitor-1.html">Src Inhibitor 1</a>產(chǎn)品描述：Src Inhibitor 1 is a potent and selective dual site <b>Src</b> tyrosine kinase inhibitor with <b>IC<sub>50</sub></b> values of 44 nM for Src and 88nM for Lck.

IC50 & Target: IC50: 44 nM (Src), 88 nM (Lck)<sup>[1]</sup>

<i><b>In Vitro:</b></i> Src-I1 is competitive with both ATP and peptide binding sites of the kinase. The IC<sub>50</sub> values are 44 and 88 nM for Src and Lck, respectively<sup>[1]</sup>. Src-I1, is found to be a potent inhibitor of Src (IC<sub>50</sub>=0.18 μM), but also inhibited other Src family members, such as Lck, Csk and Yes with similar potency to Src, and RIP2 (IC<sub>50</sub>=0.026 μM) with even greater potency. In addition, it inhibited CHK2 with similar potency to Src, and Aurora B with slightly lower potency<sup>[2]</sup>.

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