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Navitoclax研究進(jìn)展

發(fā)布日期：2017-10-27   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/navitoclax.htmlNavitoclax/a產(chǎn)品描述：Navitoclax is a potent and orally bioavailabl
<a href="https://www.medchemexpress.com/navitoclax.html">Navitoclax</a>產(chǎn)品描述：Navitoclax is a potent and orally bioavailable <b>Bcl-2 family protein</b> inhibitor that binds with high affinity (<b>K<sub>i</sub></b> < 1 nM) to multiple anti-apoptotic Bcl-2 family proteins including Bcl-x<sub>L</sub>, Bcl-2 and Bcl-w.

IC50 & Target: Ki: < 1 nM (Bcl-x<sub>L</sub>), < 1 nM (Bcl-2), < 1 nM (Bcl-w)

<i><b>In Vitro:</b></i> Navitoclax (ABT-263) is active against approximately one-half of the cell lines of the PPTP in vitro panel. The median IC<sub>50</sub> for all of the lines in the panel is 1.91 µM<sup>[1]</sup>. Navitoclax in combination with chemotherapy agents leads most ovarian cancer cell lines a synergistic response, and enhances the caspase activation at all paclitaxel doses tested in both SK-OV-3 and IGROV-1 cell lines<sup>[2]</sup>.

<i><b>In Vivo:</b></i> Navitoclax (100 mg/kg/day, p.o.) also improves responses to bendamustine-rituximab (BR) in a subset of tumours in mice xenograft<sup>[3]</sup>.<br><br>
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已為全球多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫(kù)。</span><br><br>產(chǎn)品鏈接：<a href="http://www.medchemexpress.cn/navitoclax.html">www.medchemexpress.cn/navitoclax.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"

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