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TN1研究進(jìn)展

發(fā)布日期：2017-10-27   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/TN1.htmlTN1/a產(chǎn)品描述：TN1 is a potent fetal hemoglobin (bHbF/b) inducer.IC50Targe
<a href="https://www.medchemexpress.com/TN1.html">TN1</a>產(chǎn)品描述：TN1 is a potent fetal hemoglobin (<b>HbF</b>) inducer.

IC50 & Target: fetal hemoglobin (HbF)<sup>[1]</sup>

<i><b>In Vitro:</b></i> A high-throughput screen of a large chemical library identifies a 2,6-diamino-substituted purine, TN1, which induces fetal hemoglobin (HbF) more potently than hydroxyurea in KU812 and K562 leukemia cell lines.TN1 increases HbF protein in both leukemic KU812 and K562 cells in a dose-dependent manner. At 100 nM concentration, Western blot analysis indicated that TN1 increased γ-globin expression (2.9- and 3.7-fold increase in KU812 cell and K562 cell, respectively) to higher levels than 50-100 μM HU (1.8- and 1.9-fold increase in KU812 cell and K562 cell, respectively), the first drug approved for the treatment of SCD. The EC<sub>50</sub> value for TN1-mediated HbF induction is approximately three orders of magnitude lower than that of HU (HU: EC<sub>50</sub>=50-100 μM; TN1: EC<sub>50</sub>=100 nM). In addition, TN1 is more potent than a number of previous<br><br>
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已為全球多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫(kù)。</span><br><br>產(chǎn)品鏈接：<a href="http://www.medchemexpress.cn/tn1.html">www.medchemexpress.cn/tn1.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"

alt="">
 
 
 
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