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D-Glutamic acid研究進(jìn)展

發(fā)布日期：2017-10-27   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/D-Glutamic-acid.htmlD-Glutamic acid/a產(chǎn)品描述：D-glutamic acid, an enantiomer of L
<a href="https://www.medchemexpress.com/D-Glutamic-acid.html">D-Glutamic acid</a>產(chǎn)品描述：D-glutamic acid, an enantiomer of L- glutamic acid, is widely used in pharmaceuticals and foods.


<i><b>In Vitro:</b></i> Various d-amino acids, such as D-serine, D-aspartic acid (D-Asp), and D-glutamic acid (D-Glu) are widely found in mammals including human beings and they are now thought to be the candidates of novel physiologically active substances and/or biomarkers<sup>[1]</sup>. D-[Asp/Glu] (4 mg/mL) inhibits IgE binding (75%) to peanuts while D-Glu, D-Asp has no inhibitory effect. IgE is specific for D-[Asp/Glu] and may have the potential for removing IgE or reducing IgE binding to peanut allergens<sup>[2]</sup>.

<i><b>In Vivo:</b></i> D-glutamic acid is currently paid attention as a modulator of neuronal transmission and hormonal secretion. It is metabolized only by D-aspartate oxidase in mammals<sup>[1]</sup>. After intraperitoneal injection, L-glutamate is catabolized via a-ketoglutarate, wheras D-glutamate is converted to n-pyrrolidone carboxylic acid. Carbon 2 of both <br><br>
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