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BMT-145027

發(fā)布日期：2017-10-26   瀏覽次數：0
核心提示：a href=https://www.medchemexpress.com/BMT-145027.htmlBMT-145027/a產品描述：BMT-145027 is an bmGluR5/b positive allosteri
<a href="https://www.medchemexpress.com/BMT-145027.html">BMT-145027</a>產品描述：BMT-145027 is an <b>mGluR5</b> positive allosteric modulator without inherent agonist activity, exhibits an <b>EC<sub>50</sub></b> of 47 nM.

IC50 & Target: IC50: 47 nM (mGluR5)<sup>[1]</sup>

<i><b>In Vitro:</b></i> BMT-145027 is a compound with high MsLM stability (85% remaining), acceptable potency (EC<sub>50</sub>=47 nM), and a modest decrease in planarity (Fsp3 = 0.17). importantly, BMT-145027 lacks inherent mGluR5 agonist activity when tested at concentrations up to 16 μM<sup>[1]</sup>.

<i><b>In Vivo:</b></i> Drug-treated and control mice are shown two identical objects. After a 24-h natural forgetting period, the mice are reintroduced to a familiar object while simultaneously presented with a novel object. Since mice spend more time exploring unfamiliar objects, improved memory is measured as time spent exploring the novel object. BMT-145027 leads to a significant increase in time spent with the novel object when dosed at 30 mg/kg, with an apparent trend in novel object prefer<br><br>
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已為全球多個知名企業(yè)、院校構建各種定制型化合物庫。</span><br><br>產品鏈接：<a href="http://www.medchemexpress.cn/bmt-145027.html">www.medchemexpress.cn/bmt-145027.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

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