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CA-074 methyl ester

發(fā)布日期：2017-10-26   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/CA-074-methyl-ester.htmlCA-074 methyl ester/a產(chǎn)品描述：CA-074 methyl ester is a sp
<a href="https://www.medchemexpress.com/CA-074-methyl-ester.html">CA-074 methyl ester</a>產(chǎn)品描述：CA-074 methyl ester is a specific inhibitor of <b>Cathepsin B</b>, which has potent bioactivities such as neuroprotective, anti-cancer, and anti-inflamatory effects.

<i><b>In Vitro:</b></i> CA-074Me (5 μM and 50 μM) inhibits RANKL-induced osteoclastogenesis in BMM cells derived from C57BL/6J and NOD/ShiLtJ mice. CA-074Me exerts its anti-osteoclastogenic effect within 24 hours post-RANKL stimulation in vitro. CA-074Me does not exert its anti-osteoclastogenic effect via the MAPK-ERK signaling cascade. CA-074Me inhibits c-FOS upregulation and subsequent NFATc1 autoamplification following RANKL stimulation.<sup>[2]</sup>. CA-074Me reduces apoptosis induced by CVB1<sup>[3]</sup>.

<i><b>In Vivo:</b></i> Hippocampal CA1 neuronal programmed necrosis induced by global cerebral I/R injury is prevented by CA074-me (1 μg, 10 μg) both pre-treatment and post-treatment. The rupture of lysosomal membrane and the leakage of cathepsin-B, and this is strongly inhibited by CA074-me pre-treatment. The <br><br>
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