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JNJ16259685

發(fā)布日期：2017-10-26   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/JNJ16259685.htmlJNJ16259685/a產(chǎn)品描述：JNJ16259685 is a selective antagonist of bm
<a href="https://www.medchemexpress.com/JNJ16259685.html">JNJ16259685</a>產(chǎn)品描述：JNJ16259685 is a selective antagonist of <b>mGlu1 receptor</b>, and inhibits the synaptic activation of mGlu1 in a concentration-dependent manner with <b>IC<sub>50</sub></b> of 19 nM.

IC50 & Target: IC50: 19 nM (mGlu1)

<i><b>In Vitro:</b></i> JNJ16259685 potently and completely inhibits the glutamate (30 μM)-induced increase in intracellular Ca<sup>2+</sup> concentrations at the rat mGlu1a receptor with an IC<sub>50</sub> value of 3.24±1.00 nM. IC<sub>50</sub> values for CPCCOEt and BAY 36-7620 are 17.8±10.3 μM and 161±38 nM, respectively. The potency of JNJ16259685 in blocking glutamate (30 μM)-induced Ca<sup>2+</sup> mobilization at the human mGlu1a receptor is 1.21±0.53 nM (IC<sub>50</sub> n=3). JNJ16259685 inhibits the glutamate (3 μM)-induced rise in intracellular Ca<sup>2+</sup> concentrations at the rat mGlu5a receptor with an IC<sub>50</sub> value of 1.31±0.39 μM (n=4). JNJ16259685 blocks glutamate (3 μM)-induced Ca<sup>2+</sup> mobilization at the human mGlu5 receptor with <br><br>
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<span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);">公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動(dòng)劑、API及化合物庫，總部位于美國(guó)新澤西，分別在瑞典和上海設(shè)有歐洲區(qū)子公司和亞洲區(qū)總代理，營(yíng)銷網(wǎng)點(diǎn)遍及全球20多個(gè)國(guó)家地區(qū)。MCE經(jīng)過多年努力已成為全球生物活性小分子領(lǐng)域的一流供應(yīng)商， 產(chǎn)品涵蓋癌癥、神經(jīng)科學(xué)、抗感染、表觀遺傳學(xué)等20個(gè)熱門研究領(lǐng)域，PI3K、MAPK等近千個(gè)細(xì)分靶點(diǎn)，超過4000個(gè)活性小分子化合物現(xiàn)貨，以及GPCR、API、離子通道等超過20種不同類型的化合物庫，同時(shí)提供從毫克到千克的專業(yè)定制合成服務(wù)。</span>
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已為全球多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a href="http://www.medchemexpress.cn/jnj16259685.html">www.medchemexpress.cn/jnj16259685.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"

alt="">
 
 
 
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