Birinapant 是一種二價 Smac 類似物,為XIAP 和 cIAP1的有效拮抗劑,Kd 值分別為 45 nM 和 < 1 nM。
Omecamtiv mecarbil產(chǎn)品描述:Omecamtiv mecarbil is a selective myosin activator, used for the treatment of cardiovascular diseases. In Vitro: Omecamtiv mecarbil (10 μM) reduces the maximal ATPase (kcat) 4.5-fold and dramatically reduces the actin concentration at which ATPase is half-maximal (KATPase) 30-fold. The Omecamtiv mecarbil-induced inhibition of the actin-activated ATPase is evaluated in a concentration-dependent manner to determine the EC50 (0.52 ± 0.10 μM). Omecamtiv mecarbil does not change the overall actin affinity. Omecamtiv mecarbil traps a population of myosin heads in a weak actin affinity state with slow product release. Omecamtiv mecarbil can reduce the actin sliding velocity more than 100-fold in the in vitro motility assay[3]. In Vivo: Omecamtiv mecarbil (100-1000 ng/mL) demonstrates concentration-dependent increases in FS in Sprague?Dawley rats model. Omecamtiv mecarbil demonstrates good PK parameters in both
公司介紹:MedChemExpress(MCE)專注于各種抑制劑、激動劑、API及化合物庫,總部位于美國新澤西,分別在瑞典和上海設(shè)有歐洲區(qū)子公司和亞洲區(qū)總代理,營銷網(wǎng)點遍及全球20多個國家地區(qū)。MCE經(jīng)過多年努力已成為全球生物活性小分子領(lǐng)域的一流供應(yīng)商, 產(chǎn)品涵蓋癌癥、神經(jīng)科學(xué)、抗感染、表觀遺傳學(xué)等20個熱門研究領(lǐng)域,PI3K、MAPK等近千個細(xì)分靶點,超過4000個活性小分子化合物現(xiàn)貨,以及GPCR、API、離子通道等超過20種不同類型的化合物庫,同時提供從毫克到千克的專業(yè)定制合成服務(wù)。
MCE 對每批產(chǎn)品都進(jìn)行嚴(yán)格的LCMS和NMR檢驗,其產(chǎn)品已被全球近萬名客戶廣泛使用并發(fā)表大量文章、專利;
MCE 定期增加各領(lǐng)域熱門抑制劑、激動劑,不斷擴(kuò)增已有化合物庫,以滿足最新的科研需求;
數(shù)千種產(chǎn)品在上海有充足備貨,24-48小時內(nèi)送達(dá)客戶;
大量產(chǎn)品提供免費(fèi)試用裝; 已為全球多個知名企業(yè)、院校構(gòu)建各種定制型化合物庫。
產(chǎn)品鏈接:www.medchemexpress.cn/Omecamtiv-mecarbil.html
Purity:98%
MWt:806.9409
Formula:C42H56F2N8O6
SMILES:FC1=CC2=C(C=C1)C(C[C@H]3N(C([C@@H](NC([C@@H](NC)C)=O)CC)=O)C[C@@H](O)C3)=C(C(N4)=C(C[C@H]5N(C([C@@H](NC([C@@H](NC)C)=O)CC)=O)C[C@@H](O)C5)C6=C4C=C(F)C=C6)N2
Pathway:Apoptosis;
Mechanisms:IAP;
Research Area:Cancer
電話: 021-58955995
網(wǎng)址: www.MedChemExpress.cn
地址: 上海市浦東新區(qū)蔡倫路720號2號樓3層
Omecamtiv mecarbil產(chǎn)品描述:Omecamtiv mecarbil is a selective myosin activator, used for the treatment of cardiovascular diseases. In Vitro: Omecamtiv mecarbil (10 μM) reduces the maximal ATPase (kcat) 4.5-fold and dramatically reduces the actin concentration at which ATPase is half-maximal (KATPase) 30-fold. The Omecamtiv mecarbil-induced inhibition of the actin-activated ATPase is evaluated in a concentration-dependent manner to determine the EC50 (0.52 ± 0.10 μM). Omecamtiv mecarbil does not change the overall actin affinity. Omecamtiv mecarbil traps a population of myosin heads in a weak actin affinity state with slow product release. Omecamtiv mecarbil can reduce the actin sliding velocity more than 100-fold in the in vitro motility assay[3]. In Vivo: Omecamtiv mecarbil (100-1000 ng/mL) demonstrates concentration-dependent increases in FS in Sprague?Dawley rats model. Omecamtiv mecarbil demonstrates good PK parameters in both
公司介紹:MedChemExpress(MCE)專注于各種抑制劑、激動劑、API及化合物庫,總部位于美國新澤西,分別在瑞典和上海設(shè)有歐洲區(qū)子公司和亞洲區(qū)總代理,營銷網(wǎng)點遍及全球20多個國家地區(qū)。MCE經(jīng)過多年努力已成為全球生物活性小分子領(lǐng)域的一流供應(yīng)商, 產(chǎn)品涵蓋癌癥、神經(jīng)科學(xué)、抗感染、表觀遺傳學(xué)等20個熱門研究領(lǐng)域,PI3K、MAPK等近千個細(xì)分靶點,超過4000個活性小分子化合物現(xiàn)貨,以及GPCR、API、離子通道等超過20種不同類型的化合物庫,同時提供從毫克到千克的專業(yè)定制合成服務(wù)。
MCE 對每批產(chǎn)品都進(jìn)行嚴(yán)格的LCMS和NMR檢驗,其產(chǎn)品已被全球近萬名客戶廣泛使用并發(fā)表大量文章、專利;
MCE 定期增加各領(lǐng)域熱門抑制劑、激動劑,不斷擴(kuò)增已有化合物庫,以滿足最新的科研需求;
數(shù)千種產(chǎn)品在上海有充足備貨,24-48小時內(nèi)送達(dá)客戶;
大量產(chǎn)品提供免費(fèi)試用裝; 已為全球多個知名企業(yè)、院校構(gòu)建各種定制型化合物庫。
產(chǎn)品鏈接:www.medchemexpress.cn/Omecamtiv-mecarbil.html
Purity:98%
MWt:806.9409
Formula:C42H56F2N8O6
SMILES:FC1=CC2=C(C=C1)C(C[C@H]3N(C([C@@H](NC([C@@H](NC)C)=O)CC)=O)C[C@@H](O)C3)=C(C(N4)=C(C[C@H]5N(C([C@@H](NC([C@@H](NC)C)=O)CC)=O)C[C@@H](O)C5)C6=C4C=C(F)C=C6)N2
Pathway:Apoptosis;
Mechanisms:IAP;
Research Area:Cancer
電話: 021-58955995
網(wǎng)址: www.MedChemExpress.cn
地址: 上海市浦東新區(qū)蔡倫路720號2號樓3層