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目錄號(hào): HY-13635

發(fā)布日期:2017-11-27   瀏覽次數(shù):0
核心提示:目錄號(hào): HY-13635bra href=http://www.medchemexpress.cn/Pathways/Metabolic Enzyme_Protease.htmlspanMetabolic Enzyme/Protea
"目錄號(hào): HY-13635
metabolic Enzyme/Protease            -               
Finasteride是口服活性的睪酮5α-還原酶抑制劑,Ki為10 nM。
5 alpha Reductase
相關(guān)產(chǎn)品
Dutasteride  -  Finasteride acetate  -  CGP-53153  -  
生物活性
Description
                                                             Finasteride is an orally active testosterone 5-alpha-reductase inhibitor (Ki= 10 nM). Target: 5-alpha ReductaseApproved: 1992Finasteride, a synthetic 4-azasteroid antiandrogen compound, is a specific inhibitor of steroid Type II 5α-reductase, an intracellular enzyme that converts the androgen testosterone into 5α-dihydrotestosterone (DHT). Finasteride is used in the treatment of prostate cancer, benign prostatic hyperplasia, and androgenetic alopecia (male pattern baldness). In benign prostatic hyperplasia, finasteride inhibits 5alpha-reductase activity in epithelium for Ki of 10 nM, significantly lower than in stroma (Ki = 33nM) [1].
                                                   
                                                                                                                                                                    Clinical Trial
                                                                                                                                                                                                                                                                                                           NCT01133444
                                            Dr. Reddy's Laboratories Limited
                                            Healthy
                                            April 2002
                                            Phase 1
                                                                                                                                                                                                            NCT01133457
                                            Dr. Reddy's Laboratories Limited
                                            Healthy
                                            April 2002
                                            Phase 1
                                                                                                                                                                                                            NCT01264289
                                            Dr. Reddy's Laboratories Limited
                                            Healthy
                                            November 2006
                                            Phase 1
                                                                                                                                                                                                            NCT01264302
                                            Dr. Reddy's Laboratories Limited
                                            Healthy
                                            November 2006
                                            Phase 1
                                                                                                                                                                                                            NCT00542243
                                            University Health Network, Toronto-Merck Frosst Canada Ltd.
                                            Enlarged Prostate
                                            February 2008
                                            Phase 3
                                                                                                                                                                                                                                                                                                                                    NCT01296672
                                            The University of Texas Health Science Center at San Antonio-National Institutes of Health (NIH)-National Cancer Institute (NCI)
                                            Prostate Cancer
                                            February 2011
                                            Phase 4
                                                                                                                                                                                                            NCT01585441
                                            National Eye Institute (NEI)-The EMMES Corporation-National Institutes of Health Clinical Center (CC)
                                            Retinal Disease
                                            April 2012
                                            Phase 2
                                                                                                                                                                                                            NCT02548117
                                            Baylor College of Medicine
                                            ERYTHROCYTOSIS
                                            February 2016
                                            Phase 3
                                                                                                                                                                                                            NCT00837252
                                            National Eye Institute (NEI)-National Institutes of Health Clinical Center (CC)
                                            Retinal Disease
                                            February 2009
                                            Phase 1-Phase 2
                                                                                                                                                                                                            NCT01227993
                                            National Eye Institute (NEI)-National Institutes of Health Clinical Center (CC)
                                            Retinal Disease
                                            October 2010
                                            Phase 1-Phase 2
                                                                                                                                                                                                            NCT00600691
                                            University of British Columbia-Health Canada-Merck Frosst Canada Ltd.
                                            Hematuria-Hematospermia
                                            March 2008
                                            Phase 2
                                                                                                                                                                                                            NCT00564460
                                            University of Alberta-Merck Frosst Canada Ltd.
                                            Benign Prostatic Hyperplasia
                                            February 2008
                                            Phase 3
                                                                                                                                                                                                            NCT00130767
                                            Hospices Civils de Lyon
                                            Benign Prostatic Hyperplasia
                                            December 2004
                                            Phase 4
                                                                                                                                                                                                            NCT00871247
                                            Actavis Inc.
                                            Healthy
                                            November 2004
                                            Phase 1
                                                                                                                                                                                                            NCT00870480
                                            Actavis Inc.
                                            Healthy
                                            November 2004
                                            Phase 1
                                                                                                                                                                                                            NCT00564252
                                            Iran University of Medical Sciences-Firuzgar hospital affiliated to Iran University of Medical Sciences
                                            Idiopathic Hirsutism
                                            February 2006
                                           
                                                                                                                                                                                                            NCT02146937
                                            Sidney Kimmel Comprehensive Cancer Center
                                            Detectable Prostate Nodules
                                            March 2014
                                            Phase 2
                                                                                                                                                                                                            NCT02055170
                                            CancerCare Manitoba
                                            Non-small Cell Lung Cancer
                                            June 2014
                                            Phase 2
                                                                                                                                                                                                            NCT02248701
                                            VA Office of Research and Development-University of Florida
                                            Spinal Cord Injury-Spinal Cord Injuries-Trauma, Nervous System-Wounds and Injuries-Central Nervous System Diseases-Nervous System Diseases-Spinal Cord Diseases-Gonadal Disorders-Endocrine System Diseases-Hypogonadism-Genital Diseases, Male
                                            January 16, 2017
                                            Phase 2
                                                                                                                                                                                                            NCT01829893
                                            Korea University Anam Hospital-GL Pharm Tech Corporation
                                            Benign Prostatic Hyperplasia (BPH)
                                            January 2012
                                            Phase 1
                                                                                                                                                                                                            NCT00835796
                                            Teva Pharmaceuticals USA
                                            Healthy
                                            June 2002
                                            Phase 1
                                                                                                                                                                                                            NCT00835666
                                            Teva Pharmaceuticals USA
                                            Healthy
                                            June 2002
                                            Phase 1
                                                                                                                                                                                                            NCT01534351
                                            Merck Sharp & Dohme Corp.
                                            Benign Prostatic Hyperplasia
                                            August 1, 2013
                                            Phase 3
                                                                                                                                                                                                            NCT01052870
                                            HairDx, LLC
                                            Androgenetic Alopecia
                                            December 2008
                                            Phase 1
                                                                                                                                                                                                            NCT02502669
                                            Elorac, Inc.
                                            NODULOCYSTIC ACNE
                                            July 2015
                                            Phase 2
                                                                                                                                                                                                            NCT00438464
                                            National Cancer Institute (NCI)-M.D. Anderson Cancer Center
                                            Adenocarcinoma of the Prostate-Stage II Prostate Cancer
                                            February 2007
                                            Phase 2
                                                                                                                                                                                                            NCT00650377
                                            Mylan Pharmaceuticals
                                            Healthy
                                            October 2004
                                            Phase 1
                                                                                                                                                                                                            NCT00648791
                                            Mylan Pharmaceuticals
                                            Healthy
                                            September 2004
                                            Phase 1
                                                                                                                                                                                                            NCT01174953
                                            University of Kansas-University of Kansas Medical Center
                                            Prostate Cancer
                                            July 2010
                                           
                                                                                                                                                                                                            NCT01391156
                                            Mae Fah Luang University Hospital
                                            Androgenetic Alopecia
                                            March 2011
                                            Phase 3
                                                                                                                                                                                                            NCT02483195
                                            University of Florida
                                            Female Androgenetic Alopecia
                                            August 2016
                                            Phase 4
                                                                                                                                                                                                            NCT02244229
                                            Boehringer Ingelheim
                                            Prostatic Hyperplasia
                                            April 1998
                                            Phase 4
                                                                                                                                                                                                            NCT00736645
                                            Roswell Park Cancer Institute
                                            Prostate Cancer
                                            August 2008
                                            Phase 2
                                                                                                                                                                                                            NCT00396175
                                            Merck Sharp & Dohme Corp.
                                            Androgenetic Alopecia
                                            March 1998
                                            Phase 3
                                                                                                                                                                                                            NCT01231607
                                            GlaxoSmithKline
                                            Androgenetic Alopecia
                                            October 2010
                                            Phase 3
                                                                                                                                                                                                            NCT01923090
                                            University of Birmingham
                                            Healthy Volunteers
                                            August 2012
                                            Phase 2
                                                                                                                                                                                                            NCT02791243
                                            Polichem S.A.
                                            Androgenetic Alopecia
                                            May 9, 2016
                                            Phase 1
                                                                                                                                                                                                            NCT01139762
                                            Eli Lilly and Company
                                            Benign Prostatic Hyperplasia-Enlarged Prostate
                                            September 2010
                                            Phase 3
                                                                                                                                                                                                            NCT01736033
                                            Seoul National University Hospital-Astellas Pharma Korea, Inc.-Medical Research Collaborating Center, Seoul, Korea
                                            Benign Prostate Hyperplasia
                                            February 2012
                                            Phase 4
                                                                                                                                                                                                            NCT02703220
                                            VA Office of Research and Development
                                            Sleep Apnea-Elderly Adults
                                            July 3, 2015
                                            Phase 4
                                                                                                                                                                                                            NCT03004469
                                            Polichem S.A.
                                            Alopecia, Androgenetic
                                            July 2016
                                            Phase 3
                                                                                                                                                                                                            NCT00475501
                                            VA Office of Research and Development-Endo Pharmaceuticals-Merck Sharp & Dohme Corp.
                                            Male Hypogonadism-Muscle Atrophy-Sarcopenia-Benign Prostate Hypertrophy
                                            January 2007
                                            Phase 2
                                                                                                                                                                                                            NCT00759135
                                            Nymox Corporation
                                            Benign Prostatic Hyperplasia (BPH)-Enlarged Prostate
                                            May 2007
                                            Phase 2
                                                                                                                                                                                                            NCT00064649
                                            National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)-Diagnostic Ultrasound-Urologix-Medtronic-Merck Sharp & Dohme Corp.-Sanofi-Synthelabo
                                            Benign Prostatic Hyperplasia
                                            April 2004
                                            Phase 3
                                                                                                                                                                                                            NCT00021814
                                            National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
                                            Prostatic Hyperplasia-Prostatic Hypertrophy, Benign
                                            December 1995
                                            Phase 3
                                                                                                                                                                                                            NCT01342367
                                            University of Chicago
                                            Prostate Cancer
                                            December 2010
                                           
                                                                                                                                                                                                            NCT00663793
                                            University of Washington-National Institutes of Health (NIH)-Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
                                            Contraception-Hypogonadism
                                            October 2008
                                            Phase 1
                                                                                                                                                                                                            NCT00003323
                                            Alliance for Clinical Trials in Oncology-National Cancer Institute (NCI)
                                            Prostate Cancer-Sexual Dysfunction and Infertility
                                            May 1998
                                            Phase 2
                                                                                                                                                                                                            NCT01643629
                                            Kasiak Research Pvt. Ltd.
                                            Androgenetic Alopecia
                                            January 2012
                                            Phase 1-Phase 2
                                                                                                                                                                                                            NCT00127179
                                            Merck Sharp & Dohme Corp.
                                            Benign Prostatic Hyperplasia
                                            January 1, 2004
                                            Phase 3
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                                                                                        References
[1]. Weisser, H. and M. Krieg, In vitro inhibition of androstenedione 5alpha-reduction by finasteride in epithelium and stroma of human benign prostatic hyperplasia. J Steroid Biochem Mol Biol, 199

 
 
 
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