Nosantine racemate 是 Nosantine 的外消旋體。Nosantine是一種 IL-2 誘導劑或誘導 IL-2 的增強劑。 CA-074 methyl ester產(chǎn)品描述:CA-074 methyl ester is a specific inhibitor of Cathepsin B, which has potent bioactivities such as neuroprotective, anti-cancer, and anti-inflamatory effects.In Vitro: CA-074Me (5 μM and 50 μM) inhibits RANKL-induced osteoclastogenesis in BMM cells derived from C57BL/6J and NOD/ShiLtJ mice. CA-074Me exerts its anti-osteoclastogenic effect within 24 hours post-RANKL stimulation in vitro. CA-074Me does not exert its anti-osteoclastogenic effect via the MAPK-ERK signaling cascade. CA-074Me inhibits c-FOS upregulation and subsequent NFATc1 autoamplification following RANKL stimulation.[2]. CA-074Me reduces apoptosis induced by CVB1[3]. In Vivo: Hippocampal CA1 neuronal programmed necrosis induced by global cerebral I/R injury is prevented by CA074-me (1 μg, 10 μg) both pre-treatment and post-treatment. The rupture of lysosomal membrane and the leakage of cathepsin-B, and this is strongly inhibited by CA074-me pre-treatment. The 公司介紹:MedChemExpress(MCE)專注于各種抑制劑、激動劑、API及化合物庫,總部位于美國新澤西,分別在瑞典和上海設(shè)有歐洲區(qū)子公司和亞洲區(qū)總代理,營銷網(wǎng)點遍及全球20多個國家地區(qū)。MCE經(jīng)過多年努力已成為全球生物活性小分子領(lǐng)域的一流供應商, 產(chǎn)品涵蓋癌癥、神經(jīng)科學、抗感染、表觀遺傳學等20個熱門研究領(lǐng)域,PI3K、MAPK等近千個細分靶點,超過4000個活性小分子化合物現(xiàn)貨,以及GPCR、API、離子通道等超過20種不同類型的化合物庫,同時提供從毫克到千克的專業(yè)定制合成服務。 MCE 對每批產(chǎn)品都進行嚴格的LCMS和NMR檢驗,其產(chǎn)品已被全球近萬名客戶廣泛使用并發(fā)表大量文章、專利; MCE 定期增加各領(lǐng)域熱門抑制劑、激動劑,不斷擴增已有化合物庫,以滿足最新的科研需求; 數(shù)千種產(chǎn)品在上海有充足備貨,24-48小時內(nèi)送達客戶; 大量產(chǎn)品提供免費試用裝;已為全球多個知名企業(yè)、院校構(gòu)建各種定制型化合物庫。 產(chǎn)品鏈接:www.medchemexpress.cn/CA-074-methyl-ester.html Purity:98% MWt:278.3501 Formula:C14H22N4O2 SMILES:O=C1N=CNC2=C1N=CN2C(C(O)C)CCCCCC Pathway:Immunology/Inflammation; Mechanisms:Interleukin Related; Research Area:Inflammation/Immunology 電話: 021-58955995 網(wǎng)址: www.MedChemExpress.cn 地址: 上海市浦東新區(qū)蔡倫路720號2號樓3層 |
Nosantine (racemate)前沿研究進展
發(fā)布日期:2017-11-13 瀏覽次數(shù):2
核心提示:Nosantine racemate 是 Nosantine 的外消旋體。Nosantine是一種 bIL-2/b 誘導劑或誘導 bIL-2/b 的增強劑。BRa href=https://www.
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