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Polyoxyethylene stearate研究進(jìn)展

發(fā)布日期：2017-10-30   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/Polyoxyethylene_stearate.htmlPolyoxyethylene stearate/a產(chǎn)品描述：Polyoxyethylene s
<a href="https://www.medchemexpress.com/Polyoxyethylene_stearate.html">Polyoxyethylene stearate</a>產(chǎn)品描述：Polyoxyethylene stearate (POES) is a non-ionic emulsifying agent.

<i><b>In Vitro:</b></i> Polyoxyethylene stearate has been recommended as an additive to the radiolabelled 7H12 Middlebrook TB media and as such has been shown to enhance growth of mycobacteria in the radiometric BACTEC rapid culture system. Polyoxyethylene (50) stearate produces the greatest enhancement in growth and reduction in the time taken to detect growth for <i>M. tuberculosis</i> and polyoxyethylene (30) stearate and polyoxyethylene (JL) stearate for species of mycobacteria other than <i>M. tuberculosis</i><sup>[1]</sup>. Polyoxyethylene stearate inhibits P-gp mediated efflux in a concentration dependent manner mainly by modulating substrate-stimulated P-gp ATPase activity<sup>[2]</sup>. Polyoxyethylene 40 stearate reduces vinblastine sulfate efllux. The cytotoxicity of vinblastine to K562/ADR cells is significantly enhanced when the cells are cotreated with 100 or 150 μg/mL polyoxyethylene 40 stearate<sup>[3]<br><br>
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