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AK-1研究進(jìn)展

發(fā)布日期：2017-10-30   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/AK-1.htmlAK-1/a產(chǎn)品描述：AK-1 is a potent, specific and cell-permeable bSIRT2/b in
<a href="https://www.medchemexpress.com/AK-1.html">AK-1</a>產(chǎn)品描述：AK-1 is a potent, specific and cell-permeable <b>SIRT2</b> inhibitor.

<i><b>In Vitro:</b></i> AK-1 achieves significant neuroprotection in Huntington’s disease flies at 10 μM, improving the number of rhabdomeres from 5.2 to 5.6<sup>[1]</sup>. AK-1 treatment induces proteasomal degradation of the Snail transcription factor through inactivation of the NF-κB/CSN2 pathway. Reduction in the level of Snail results in upregulation of p21, leading to G1 arrest, slow proliferation, and slow wound-healing activity. The regulation of Snail-p21 axis by AK-1 also occurs in HT-29 colon cancer cells<sup>[2]</sup>. Under hypoxic conditions, AK-1 increases the ubiquitination of HIF-1α in a VHL-dependent manner, leading to the degradation of HIF-1α via a proteasomal pathway. Downregulation of HIF-1α expression reduces its transcriptional activity and, eventually, reduces the expression of BNIP3, one of HIF-1 target genes, in AK-1-treated cells<sup>[3]</sup>.

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已為全球多個知名企業(yè)、院校構(gòu)建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a href="http://www.medchemexpress.cn/ak-1.html">www.medchemexpress.cn/ak-1.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

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