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Paprotrain研究進(jìn)展

發(fā)布日期：2017-10-27   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/Paprotrain.htmlPaprotrain/a產(chǎn)品描述：Paprotrain is a cell-permeable inhibitor of t
<a href="https://www.medchemexpress.com/Paprotrain.html">Paprotrain</a>產(chǎn)品描述：Paprotrain is a cell-permeable inhibitor of the <b>kinesin</b> MKLP-2 and shows a moderate inhibition activity on <b>DYRK1A</b> with an <b>IC<sub>50</sub></b> of 5.5 μM.

IC50 & Target: IC50: 5.5 μM (DYRK1A)<sup>[1]</sup>

<i><b>In Vitro:</b></i> Paprotrain has been screened on a panel of CNS kinases. While inactive (IC<sub>50</sub> >10 μM) on CDK5 and GSK3, it has shown a moderate activity on DYRK1A (IC<sub>50</sub>=5.5 μM)<sup>[1]</sup>. Time-lapse microscopy shows that disrupting MKlp2 expression with paprotrain results in polar body extrusion failure. This could be rescued after rescuing oocytes from paprotrain in fresh medium. Cell cycle analysis shows that most oocytes are arrested at metaphase I or telophase I. However, oocyte spindle structure and chromosome alignment are not disrupted after the inhibition of MKlp2 by paprotrain<sup>[2]</sup>. Paprotrain-treated porcine oocytes suffer failure of nuclear maturation. The number of oocytes arrested at early MI stage increase in a<br><br>
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已為全球多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a href="http://www.medchemexpress.cn/paprotrain.html">www.medchemexpress.cn/paprotrain.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"

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