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Conduritol B epoxide研究進(jìn)展

發(fā)布日期：2017-10-27   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/Conduritol-B-epoxide.htmlConduritol B epoxide/a產(chǎn)品描述：Conduritol B epoxide is a
<a href="https://www.medchemexpress.com/Conduritol-B-epoxide.html">Conduritol B epoxide</a>產(chǎn)品描述：Conduritol B epoxide is an irreversible covalently bound <b>acid β-glucosidase (GCase)</b> inhibitor, with <b>IC<sub>50</sub></b>s of 1 and 100 μM for β-glucosidase and α-glucosidase respectively.

IC50 & Target: IC50: 1 μM (β-glucosidase), 100 μM (α-glucosidase)

<i><b>In Vitro:</b></i> Treating N2a and Conduritol B epoxide-N2a cells with G6 gave GC reductions to 7% and 26% of untreated levels, respectively. G6 treated Conduritol B epoxide-N2a also has significantly decreased GS. Co-treatment of G6 and dantrolene of Conduritol B epoxide-N2a cells lead to a similar degree of GC and GS reduction as G6 alone, indicating a specific effect of G6 on inhibition of substrate accumulation, Conduritol B epoxide-N2a cells have higher calcium levels than in N2a cells without caffeine at baseline. Conduritol B epoxide-N2a cells show a significant increase in cytosolic calcium levels compared to N2a cells. Conduritol B epoxide-N2a cells show a significant reduction in OCR as evidenced by approxima<br><br>
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