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Ro 41-1049 (hydrochloride)

發(fā)布日期：2017-10-26   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/Ro-41-1049-hydrochloride.htmlRo 41-1049 (hydrochloride)/a產(chǎn)品描述：Ro 41-1049 hydr
<a href="https://www.medchemexpress.com/Ro-41-1049-hydrochloride.html">Ro 41-1049 (hydrochloride)</a>產(chǎn)品描述：Ro 41-1049 hydrochloride is a selective, reversible, orally-active MAO-A inhibitor.

Target: MAO

in vivo: Ro 41-1049 is an inhibitor of the enzyme monoamine oxidase type A (MAO-A) to rats and monitored extracellular catecholamine levels in the corpus striatum before and after the intraperitoneal (IP) administration of a bolus of L-dopa. Acute administration of Ro 41-1049 (1-50 mg/kg IP) produced a dose-dependent decrease in basal levels of the dopamine metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) and an increase in basal levels of dopamine. In rats treated with Ro 41-1049 (20 mg/kg IP), L-dopa administration (100 mg/kg IP) produced a greater increase in striatal levels of dopamine than it did in controls, while DOPAC and HVA formation was attenuated. We conclude that inhibition of central MAO-A activity promotes synaptic accumulation of dopamine following administration of pharmacological doses of L-dopa.<br><br>
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