167869-21-8：產(chǎn)品說明書

167869-21-8：產(chǎn)品說明書

                                                <a href="https://www.medchemexpress.com/PD98059.html">PD98059</a>產(chǎn)品描述：PD98059 is an <b>MEK</b> inhibitor with <b>IC₅₀</b> of 5 μM, also suppresses TCDD binding to the aryl hydrocarbon receptor (AHR) with <b>IC₅₀</b> of 4 μM.IC50 &amp; Target: IC50: 5 μM (MEK)^[1]<i><b>In Vitro:</b></i> Concentrations of PD98059 of ≤20 μM are not cytotoxic to cultured MCF10A, MCF10A-Neo, and MCF10A-NeoT cells. However, PD98059 is weakly cytostatic to all three lines at concentrations of ≥10 μM. Treatment of MCF10A-Neo and MCF10A-NeoT cultures with concentrations of PD98059 up to 20 μM for 2-22 hr does not alter the total ERK content. However, treatment with PD98059 does result in concentration-dependent reductions in the dually phosphorylated forms of ERK1 and ERK2. Within 2 hr of a 10-μM treatment, phosphorylated ERK contents are reduced ~74% and ~86% in MCF10A-Neo and MCF10A-NeoT cultures, respectively (IC₅₀=1 μM). Within 22 hr of treatment, phosphorylated ERK forms are almost completely eliminated in both cell lines^{[1]<br /><br /><span    style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);">公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動劑、API及化合物庫，總部位于美國新澤西，分別在瑞典和上海設(shè)有歐洲區(qū)子公司和亞洲區(qū)總代理，營銷網(wǎng)點(diǎn)遍及全球20多個國家地區(qū)。MCE經(jīng)過多年努力已成為全球生物活性小分子領(lǐng)域的一流供應(yīng)商， 產(chǎn)品涵蓋癌癥、神經(jīng)科學(xué)、抗感染、表觀遺傳學(xué)等20個熱門研究領(lǐng)域，PI3K、MAPK等近千個細(xì)分靶點(diǎn)，超過4000個活性小分子化合物現(xiàn)貨，以及GPCR、API、離子通道等超過20種不同類型的化合物庫，同時提供從毫克到千克的專業(yè)定制合成服務(wù)。</span><br    style="color: rgb(62,62,62);" /><span    style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);">MCE 對每批產(chǎn)品都進(jìn)行嚴(yán)格的LCMS和NMR檢驗(yàn)，其產(chǎn)品已被全球近萬名客戶廣泛使用并發(fā)表大量文章、專利；</span><br    style="color: rgb(62,62,62);" /><span    style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);">MCE 定期增加各領(lǐng)域熱門抑制劑、激動劑，不斷擴(kuò)增已有化合物庫，以滿足最新的科研需求；</span><br    style="color: rgb(62,62,62);" /><span    style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);">數(shù)千種產(chǎn)品在上海有充足備貨，24-48小時內(nèi)送達(dá)客戶；</span><br    style="color: rgb(62,62,62);" /><span    style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);">大量產(chǎn)品提供免費(fèi)試用裝；</span><span    style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);">已為全球多個知名企業(yè)、院校構(gòu)建各種定制型化合物庫。</span><br /><br />產(chǎn)品鏈接：<a    href="http://www.medchemexpress.cn/pd98059.html">www.medchemexpress.cn/pd98059.html</a><br /><br /><img    alt=""    src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg" style="width: 600.0px;height: 310.0px;" />}                                            </div>