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CC-401 (hydrochloride)研究進(jìn)展

發(fā)布日期：2017-11-01   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/CC-401-hydrochloride.htmlCC-401 (hydrochloride)/a產(chǎn)品描述：CC-401 hydrochloride is
CC-401 (hydrochloride)產(chǎn)品描述：CC-401 hydrochloride is a potent inhibitor of all three forms of JNK with Ki of 25 to 50 nM.IC50 & Target: Ki: 25 to 50 nM (JNK)[1]In Vitro: CC-401 has at least 40-fold selectivity for JNK compared with other related kinases, including p38, extracellular signal-regulated kinase (ERK), inhibitor of κB kinase (IKK2), protein kinase C, Lck, zeta-associated protein of 70 kDa (ZAP70). In cell-based assays, 1 to 5 μM CC-401 provides specific JNK inhibition. CC-401, a small molecule that is a specific inhibitor of all three JNK isoforms. CC-401 competitively binds the ATP binding site in JNK, resulting in inhibition of the phosphorylation of the N-terminal activation domain of the transcription factor c-Jun. The specificity of this inhibitor is tested in vitro using osmotic stress of the HK-2 human tubular epithelial cell line. CC-401 inhibits sorbitol-induced phosphorylation of c-Jun in a dosage-dependent manner. However, CC-401 does not


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